Depression May Accelerate Brain Aging

Individuals diagnosed with major depressive disorder (MDD) present with accelerated aging of certain brain structures such as the putamen. Published in Journal of Psychiatry & Neuroscience, the study was led and co-authored by Dr Sacchet at the Department of Psychology, Stanford University. The putamen, together with the caudate nucleus and globus pallidus, represents a part…

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Groundbreaking Study Roots Out Signs of Depression in Brain

According to a new study, depression is tied to increased functional connectivity between a brain region that is associated with not receiving rewards and experiencing punishing events (the lateral orbitofrontal cortex) and an area of the brain involved in someone’s sense of self (the precuneus). This cutting-edge discovery was published today in the journal Brain….

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Associations Between Comorbid Cigarette, Alcohol, and Marijuana Use and Psychopathology

Researchers from New York University and the University of Pittsburgh have found that in a large, community-based sample, long-term simultaneous use of alcohol, cigarettes, and marijuana was associated with psychiatric disorders in adulthood, including Antisocial Personality Disorder (ASPD), Major Depressive Episode (MDE), and Generalized Anxiety Disorder (GAD). The findings were published in the Journal of…

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Low Levels of Vitamin D in Patients With Bipolar Disorder

Over the years, researchers have pointed to a potential link between vitamin D deficiency and neuropsychiatric illness, including major depressive disorder and schizophrenia. A new report provides further evidence that confirms the association between low vitamin D and bipolar disorder. A group of Dutch researchers published their findings in the Journal of Clinical Psychopharmacology. It…

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Cognition in Depression: A Critical Domain for Health Outcomes, Measurement, and Treatment

During the past decade, it has emerged that cognitive dysfunction is a common and persistent disturbance in many adults affected by major depressive disorder (MDD).1 Indeed, aspects of cognitive functions have been a criterion item within the polythetical list of a major depressive episode (MDE) for several Diagnostic and Statistical Manual (DSM) iterations. Difficulties in…

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Brain disruptions similar across many emotional disorders

Researchers have long known that emotional disorders have a lot in common. Many often occur together, like depression and social anxiety disorder. Treatments also tend to work across multiple disorders, suggesting shared underlying elements. But perhaps the most common shared characteristic is that almost all emotional disorders involve persistent negative thinking. In an analysis of…

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Stimulating possibilities arise from brain study

Queensland researchers have identified a domino effect from a brain stimulation technique used to treat psychiatric disorders such as clinical depression. The University of Queensland and QIMR Berghofer scientists have found that transcranial magnetic stimulation (TMS) can alter activity beyond the stimulated region and throughout the connected networks of the brain. UQ Queensland Brain Institute…

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Bipolar Disorder is Linked to Chronic Pain

Pain is not unfamiliar to people with bipolar disorder. The psychological pain that comes with depression and dysphoria can be debilitating. Like most people, those with bipolar disorder also experience physical pain. Stubbed toes, sore muscles and broken ankles, bipolar disorder patients are not exempt from these just because they frequently experience emotional pain. By…

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SSRIs Target Psychological But Not Somatic Symptoms in MDD

Researchers have been questioning the degree to which SSRIs affect MDD. The evidence from meta-analyses of placebo-controlled trials implies that the pharmacological effects of SSRIs may be small and that up to 75% of symptom relief may be attributable to nonspecific placebo effects and spontaneous remission.1,2 However, researchers from Northwestern University Feinberg School of Medicine,…

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Treating Metabolic Problems May Ease Depression

Identifying and treating metabolic deficiencies in patients with treatment-resistant depression can improve symptoms and in some cases even lead to remission, according to new research. “What’s really promising about these new findings is that they indicate that there may be physiological mechanisms underlying depression that we can use to improve the quality of life in…

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