Cognition in Depression: A Critical Domain for Health Outcomes, Measurement, and Treatment

During the past decade, it has emerged that cognitive dysfunction is a common and persistent disturbance in many adults affected by major depressive disorder (MDD).1 Indeed, aspects of cognitive functions have been a criterion item within the polythetical list of a major depressive episode (MDE) for several Diagnostic and Statistical Manual (DSM) iterations. Difficulties in…

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Brain disruptions similar across many emotional disorders

Researchers have long known that emotional disorders have a lot in common. Many often occur together, like depression and social anxiety disorder. Treatments also tend to work across multiple disorders, suggesting shared underlying elements. But perhaps the most common shared characteristic is that almost all emotional disorders involve persistent negative thinking. In an analysis of…

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Stimulating possibilities arise from brain study

Queensland researchers have identified a domino effect from a brain stimulation technique used to treat psychiatric disorders such as clinical depression. The University of Queensland and QIMR Berghofer scientists have found that transcranial magnetic stimulation (TMS) can alter activity beyond the stimulated region and throughout the connected networks of the brain. UQ Queensland Brain Institute…

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Bipolar Disorder is Linked to Chronic Pain

Pain is not unfamiliar to people with bipolar disorder. The psychological pain that comes with depression and dysphoria can be debilitating. Like most people, those with bipolar disorder also experience physical pain. Stubbed toes, sore muscles and broken ankles, bipolar disorder patients are not exempt from these just because they frequently experience emotional pain. By…

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SSRIs Target Psychological But Not Somatic Symptoms in MDD

Researchers have been questioning the degree to which SSRIs affect MDD. The evidence from meta-analyses of placebo-controlled trials implies that the pharmacological effects of SSRIs may be small and that up to 75% of symptom relief may be attributable to nonspecific placebo effects and spontaneous remission.1,2 However, researchers from Northwestern University Feinberg School of Medicine,…

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Treating Metabolic Problems May Ease Depression

Identifying and treating metabolic deficiencies in patients with treatment-resistant depression can improve symptoms and in some cases even lead to remission, according to new research. “What’s really promising about these new findings is that they indicate that there may be physiological mechanisms underlying depression that we can use to improve the quality of life in…

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Cognitive Function in Depression: The Role of Melancholic Features

Investigators affiliated with University of Bologna, University of Padova, and Lumsa University in Rome, Italy, have recently reported that higher order cognitive abilities including attention/working memory, visual learning, and reasoning/problem solving skills can be used to differentiate between individuals diagnosed with melancholic or non-melancholic major depressive disorder (MDD). The results of this meta-analysis were published…

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