Understanding of the physical root of depression has been advanced, thanks to new research. Researchers have identified the lateral orbitofrontal cortex as the area of the brain affected by depression. This discovery could open up possible new treatments, say the researchers.
The study shows that depression affects the part of the brain which is implicated in non-reward — the lateral orbitofrontal cortex — so that sufferers of the disease feel a sense of loss and disappointment associated with not receiving rewards.
This area of the brain, which becomes active when rewards are not received, is also connected with the part of the brain which is involved in one’s sense of self, thus potentially leading to thoughts of personal loss and low self-esteem.
Read full article at – https://www.sciencedaily.com/releases/2016/10/161018094125.htm