Individuals diagnosed with major depressive disorder (MDD) present with accelerated aging of certain brain structures such as the putamen. Published in Journal of Psychiatry & Neuroscience, the study was led and co-authored by Dr Sacchet at the Department of Psychology, Stanford University.
The putamen, together with the caudate nucleus and globus pallidus, represents a part of the basal ganglia. The relationship between the basal ganglia and cognitive and behavioral symptoms observed in patients with depression has been known for some time. For example, it has been reported that patients with MDD have diminished putamen volumes compared with those of typical, healthy controls.