Deep brain stimulation (DBS) may be effective for relieving symptoms in treatment-resistant depression, Dutch researchers reported.
A significant decrease in depressive symptoms was observed in 10 of 25 patients given DBS of the central anterior limb of the internal capsule (vALIC), Isidoor Bergfeld, MSc, of the University of Amsterdam in the Netherlands, and colleagues reported online in JAMA Psychiatry.
The treatment was well-tolerated and elicited a partial response in six additional patients, and remission was achieved in five patients. Importantly, patients receiving sham stimulation experienced significantly more depressive symptoms than during the active treatment phase of the study, the researchers said.
“To our knowledge, this is the first study showing the efficacy of deep brain stimulation of the ventral anterior limb of the internal capsule that cannot be attributed to placebo effects,” they wrote. “Further specification of targets and the most accurate setting optimization as well as larger randomized clinical trials are necessary.”
Read the full article at http://www.medpagetoday.com/Psychiatry/Depression/57250